High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression
Identifieur interne : 000641 ( Main/Exploration ); précédent : 000640; suivant : 000642High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression
Auteurs : Marian L. Hamshere [Royaume-Uni, Irlande (pays), Pays-Bas, Italie, Allemagne, États-Unis, Australie, Suisse, Danemark, Belgique] ; Kate Langley ; Joanna Martin ; SHARIFAH SHAMEEM AGHA ; Evangelia Stergiakouli ; Richard J. L. Anney ; Jan Buitelaar ; Stephen V. Faraone ; Klaus-Peter Lesch ; Benjamin M. Neale ; Barbara Franke ; Edmund Sonuga-Barke ; Philip Asherson ; Andrew Merwood ; Jonna Kuntsi ; Sarah E. Medland ; Stephan Ripke ; Hans-Christoph Steinhausen ; Christine Freitag ; Andreas Reif ; Tobias J. Renner ; Marcel Romanos ; Jasmin Romanos ; Andreas Warnke ; Jobst Meyer ; Haukur Palmason ; Alejandro Arias Vasquez ; Nanda Lambregts-Rommelse ; Herbert Roeyers ; Joseph Biederman ; Alysa E. Doyle ; Hakon Hakonarson ; Aribert Rothenberger ; Tobias Banaschewski ; Robert D. Oades ; James J. Mcgough ; Lindsey Kent ; Nigel Williams ; Michael J. Owen ; Peter Holmans ; Michael C. O'Donovan ; Anita ThaparSource :
- The American journal of psychiatry [ 0002-953X ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
Abstract
Objective: Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence that aggression or conduct disorder in children with ADHD indexes higher genetic loading and clinical severity. The authors examine whether common genetic variants considered en masse as polygenic scores for ADHD are especially enriched in children with comorbid conduct disorder. Method: Polygenic scores derived from an ADHD GWAS meta-analysis were calculated in an independent ADHD sample (452 case subjects, 5,081 comparison subjects). Multivariate logistic regression analyses were employed to compare polygenic scores in the ADHD and comparison groups and test for higher scores in ADHD case subjects with comorbid conduct disorder relative to comparison subjects and relative to those without comorbid conduct disorder. Association with symptom scores was tested using linear regression. Results: Polygenic risk for ADHD, derived from the meta-analysis, was higher in the independent ADHD group than in the comparison group. Polygenic score was significantly higher in ADHD case subjects with conduct disorder relative to ADHD case subjects without conduct disorder. ADHD polygenic score showed significant association with comorbid conduct disorder symptoms. This relationship was explained by the aggression items.
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Affiliations:
- Allemagne, Australie, Belgique, Danemark, Irlande (pays), Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Bade-Wurtemberg, Californie, Canton de Zurich, District de Darmstadt, District de Karlsruhe, Grand Londres, Gueldre, Hesse (Land), Massachusetts, Pennsylvanie, Province de Flandre-Orientale, Rhénanie-Palatinat, Région flamande
- Boston, Francfort-sur-le-Main, Gand, Londres, Los Angeles, Mannheim, Nimègue, Philadelphie, Trèves (Allemagne), Zurich
- Université de Gand, Université de Trèves, Université de Zurich
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Renner</name></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name></author><author><name sortKey="Romanos, Jasmin" sort="Romanos, Jasmin" uniqKey="Romanos J" first="Jasmin" last="Romanos">Jasmin Romanos</name></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name></author><author><name sortKey="Palmason, Haukur" sort="Palmason, Haukur" uniqKey="Palmason H" first="Haukur" last="Palmason">Haukur Palmason</name></author><author><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name></author><author><name sortKey="Lambregts Rommelse, Nanda" sort="Lambregts Rommelse, Nanda" uniqKey="Lambregts Rommelse N" first="Nanda" last="Lambregts-Rommelse">Nanda Lambregts-Rommelse</name></author><author><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name></author><author><name sortKey="Biederman, Joseph" sort="Biederman, Joseph" uniqKey="Biederman J" first="Joseph" last="Biederman">Joseph Biederman</name></author><author><name sortKey="Doyle, Alysa E" sort="Doyle, Alysa E" uniqKey="Doyle A" first="Alysa E." last="Doyle">Alysa E. Doyle</name></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name></author><author><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name></author><author><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name></author><author><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name></author><author><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name></author><author><name sortKey="Kent, Lindsey" sort="Kent, Lindsey" uniqKey="Kent L" first="Lindsey" last="Kent">Lindsey Kent</name></author><author><name sortKey="Williams, Nigel" sort="Williams, Nigel" uniqKey="Williams N" first="Nigel" last="Williams">Nigel Williams</name></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name></author><author><name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. 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Hamshere</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry, Trinity Centre for Health Sciences</s1><s2>Dublin</s2><s3>IRL</s3></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Departments of Cognitive Neuroscience, Human Genetics, and Psychiatry, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Center</s1><s2>Nijmegen</s2><s3>NLD</s3></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Psychiatry and of Neuroscience and Physiology, State University of New York Upstate Medical University</s1><s2>Syracuse</s2><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Syracuse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>ADHD Clinical Research Network, Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics, and Psychotherapy, and Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT</s1><s2>Cambridge, Mass.</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Cambridge, Mass.</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Analytic and Translational Genetics Unit, Massachusetts General Hospital</s1><s2>Boston</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>King's College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Institute for Disorder of Impulse and Attention, School of Psychology, University of Southampton</s1><s2>Highfield, Southampton</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Highfield, Southampton</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Quantitative Genetics, Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Clinical Psychology and Epidemiology, Institute of Psychology, University of Basel</s1><s2>Basel</s2><s3>CHE</s3></inist:fA14><country>Suisse</country><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Aalborg Psychiatric Hospital, Aarhus University Hospital</s1><s2>Aarhus</s2><s3>DNK</s3></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Child and Adolescent Psychiatry, University of Zurich</s1><s2>Zurich</s2><s3>CHE</s3></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Goethe University</s1><s2>Frankfurt am Main</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="15"><s1>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier</s1><s2>Trier</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Experimental Clinical and Health Psychology, Ghent University, Dunantlaan</s1><s2>Ghent</s2><s3>BEL</s3></inist:fA14><country>Belgique</country><wicri:noRegion>Ghent</wicri:noRegion><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital</s1><s2>Boston</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Department of Psychiatry, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Center for Applied Genomics and Department of Pediatrics, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia</s1><s2>Philadelphia</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Child and Adolescent Psychiatry, University of Goettingen</s1><s2>Goettingen</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>University of Goettingen</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University</s1><s2>Mannheim</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Clinic for Child and Adolescent Psychiatry, University of Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University of Duisburg-Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>UCLA Semel Institute for Neuroscience and Human Behavior</s1><s2>Los Angeles</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>School of Medicine, St. Andrews University</s1><s2>St. Andrews</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>St. Andrews</wicri:noRegion></affiliation></author><author><name sortKey="Langley, Kate" sort="Langley, Kate" uniqKey="Langley K" first="Kate" last="Langley">Kate Langley</name></author><author><name sortKey="Martin, Joanna" sort="Martin, Joanna" uniqKey="Martin J" first="Joanna" last="Martin">Joanna Martin</name></author><author><name sortKey="Sharifah Shameem Agha" sort="Sharifah Shameem Agha" uniqKey="Sharifah Shameem Agha" last="Sharifah Shameem Agha">SHARIFAH SHAMEEM AGHA</name></author><author><name sortKey="Stergiakouli, Evangelia" sort="Stergiakouli, Evangelia" uniqKey="Stergiakouli E" first="Evangelia" last="Stergiakouli">Evangelia Stergiakouli</name></author><author><name sortKey="Anney, Richard J L" sort="Anney, Richard J L" uniqKey="Anney R" first="Richard J. L." last="Anney">Richard J. L. Anney</name></author><author><name sortKey="Buitelaar, Jan" sort="Buitelaar, Jan" uniqKey="Buitelaar J" first="Jan" last="Buitelaar">Jan Buitelaar</name></author><author><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name></author><author><name sortKey="Neale, Benjamin M" sort="Neale, Benjamin M" uniqKey="Neale B" first="Benjamin M." last="Neale">Benjamin M. Neale</name></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name></author><author><name sortKey="Sonuga Barke, Edmund" sort="Sonuga Barke, Edmund" uniqKey="Sonuga Barke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name></author><author><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name></author><author><name sortKey="Merwood, Andrew" sort="Merwood, Andrew" uniqKey="Merwood A" first="Andrew" last="Merwood">Andrew Merwood</name></author><author><name sortKey="Kuntsi, Jonna" sort="Kuntsi, Jonna" uniqKey="Kuntsi J" first="Jonna" last="Kuntsi">Jonna Kuntsi</name></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name></author><author><name sortKey="Ripke, Stephan" sort="Ripke, Stephan" uniqKey="Ripke S" first="Stephan" last="Ripke">Stephan Ripke</name></author><author><name sortKey="Steinhausen, Hans Christoph" sort="Steinhausen, Hans Christoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name></author><author><name sortKey="Freitag, Christine" sort="Freitag, Christine" uniqKey="Freitag C" first="Christine" last="Freitag">Christine Freitag</name></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name></author><author><name sortKey="Romanos, Jasmin" sort="Romanos, Jasmin" uniqKey="Romanos J" first="Jasmin" last="Romanos">Jasmin Romanos</name></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name></author><author><name sortKey="Palmason, Haukur" sort="Palmason, Haukur" uniqKey="Palmason H" first="Haukur" last="Palmason">Haukur Palmason</name></author><author><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name></author><author><name sortKey="Lambregts Rommelse, Nanda" sort="Lambregts Rommelse, Nanda" uniqKey="Lambregts Rommelse N" first="Nanda" last="Lambregts-Rommelse">Nanda Lambregts-Rommelse</name></author><author><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name></author><author><name sortKey="Biederman, Joseph" sort="Biederman, Joseph" uniqKey="Biederman J" first="Joseph" last="Biederman">Joseph Biederman</name></author><author><name sortKey="Doyle, Alysa E" sort="Doyle, Alysa E" uniqKey="Doyle A" first="Alysa E." last="Doyle">Alysa E. Doyle</name></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name></author><author><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name></author><author><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name></author><author><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name></author><author><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name></author><author><name sortKey="Kent, Lindsey" sort="Kent, Lindsey" uniqKey="Kent L" first="Lindsey" last="Kent">Lindsey Kent</name></author><author><name sortKey="Williams, Nigel" sort="Williams, Nigel" uniqKey="Williams N" first="Nigel" last="Williams">Nigel Williams</name></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name></author><author><name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name></author><author><name sortKey="Thapar, Anita" sort="Thapar, Anita" uniqKey="Thapar A" first="Anita" last="Thapar">Anita Thapar</name></author></analytic><series><title level="j" type="main">The American journal of psychiatry</title><title level="j" type="abbreviated">Am. j. psychiatr.</title><idno type="ISSN">0002-953X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of psychiatry</title><title level="j" type="abbreviated">Am. j. psychiatr.</title><idno type="ISSN">0002-953X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aggression</term><term>Attention disorder with hyperactivity</term><term>Child</term><term>Concomitant disease</term><term>Polygenic</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Polygénique</term><term>Facteur risque</term><term>Trouble déficitaire de l'attention avec hyperactivité</term><term>Association morbide</term><term>Agression</term><term>Enfant</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence that aggression or conduct disorder in children with ADHD indexes higher genetic loading and clinical severity. The authors examine whether common genetic variants considered en masse as polygenic scores for ADHD are especially enriched in children with comorbid conduct disorder. Method: Polygenic scores derived from an ADHD GWAS meta-analysis were calculated in an independent ADHD sample (452 case subjects, 5,081 comparison subjects). Multivariate logistic regression analyses were employed to compare polygenic scores in the ADHD and comparison groups and test for higher scores in ADHD case subjects with comorbid conduct disorder relative to comparison subjects and relative to those without comorbid conduct disorder. Association with symptom scores was tested using linear regression. Results: Polygenic risk for ADHD, derived from the meta-analysis, was higher in the independent ADHD group than in the comparison group. Polygenic score was significantly higher in ADHD case subjects with conduct disorder relative to ADHD case subjects without conduct disorder. ADHD polygenic score showed significant association with comorbid conduct disorder symptoms. This relationship was explained by the aggression items.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Irlande (pays)</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Canton de Zurich</li><li>District de Darmstadt</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Gueldre</li><li>Hesse (Land)</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Province de Flandre-Orientale</li><li>Rhénanie-Palatinat</li><li>Région flamande</li></region><settlement><li>Boston</li><li>Francfort-sur-le-Main</li><li>Gand</li><li>Londres</li><li>Los Angeles</li><li>Mannheim</li><li>Nimègue</li><li>Philadelphie</li><li>Trèves (Allemagne)</li><li>Zurich</li></settlement><orgName><li>Université de Gand</li><li>Université de Trèves</li><li>Université de Zurich</li></orgName></list><tree><noCountry><name sortKey="Anney, Richard J L" sort="Anney, Richard J L" uniqKey="Anney R" first="Richard J. L." last="Anney">Richard J. L. Anney</name><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name><name sortKey="Biederman, Joseph" sort="Biederman, Joseph" uniqKey="Biederman J" first="Joseph" last="Biederman">Joseph Biederman</name><name sortKey="Buitelaar, Jan" sort="Buitelaar, Jan" uniqKey="Buitelaar J" first="Jan" last="Buitelaar">Jan Buitelaar</name><name sortKey="Doyle, Alysa E" sort="Doyle, Alysa E" uniqKey="Doyle A" first="Alysa E." last="Doyle">Alysa E. Doyle</name><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Freitag, Christine" sort="Freitag, Christine" uniqKey="Freitag C" first="Christine" last="Freitag">Christine Freitag</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name><name sortKey="Kent, Lindsey" sort="Kent, Lindsey" uniqKey="Kent L" first="Lindsey" last="Kent">Lindsey Kent</name><name sortKey="Kuntsi, Jonna" sort="Kuntsi, Jonna" uniqKey="Kuntsi J" first="Jonna" last="Kuntsi">Jonna Kuntsi</name><name sortKey="Lambregts Rommelse, Nanda" sort="Lambregts Rommelse, Nanda" uniqKey="Lambregts Rommelse N" first="Nanda" last="Lambregts-Rommelse">Nanda Lambregts-Rommelse</name><name sortKey="Langley, Kate" sort="Langley, Kate" uniqKey="Langley K" first="Kate" last="Langley">Kate Langley</name><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><name sortKey="Martin, Joanna" sort="Martin, Joanna" uniqKey="Martin J" first="Joanna" last="Martin">Joanna Martin</name><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><name sortKey="Merwood, Andrew" sort="Merwood, Andrew" uniqKey="Merwood A" first="Andrew" last="Merwood">Andrew Merwood</name><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><name sortKey="Neale, Benjamin M" sort="Neale, Benjamin M" uniqKey="Neale B" first="Benjamin M." last="Neale">Benjamin M. Neale</name><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name><name sortKey="Palmason, Haukur" sort="Palmason, Haukur" uniqKey="Palmason H" first="Haukur" last="Palmason">Haukur Palmason</name><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><name sortKey="Ripke, Stephan" sort="Ripke, Stephan" uniqKey="Ripke S" first="Stephan" last="Ripke">Stephan Ripke</name><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name><name sortKey="Romanos, Jasmin" sort="Romanos, Jasmin" uniqKey="Romanos J" first="Jasmin" last="Romanos">Jasmin Romanos</name><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name><name sortKey="Sharifah Shameem Agha" sort="Sharifah Shameem Agha" uniqKey="Sharifah Shameem Agha" last="Sharifah Shameem Agha">SHARIFAH SHAMEEM AGHA</name><name sortKey="Sonuga Barke, Edmund" sort="Sonuga Barke, Edmund" uniqKey="Sonuga Barke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name><name sortKey="Steinhausen, Hans Christoph" sort="Steinhausen, Hans Christoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name><name sortKey="Stergiakouli, Evangelia" sort="Stergiakouli, Evangelia" uniqKey="Stergiakouli E" first="Evangelia" last="Stergiakouli">Evangelia Stergiakouli</name><name sortKey="Thapar, Anita" sort="Thapar, Anita" uniqKey="Thapar A" first="Anita" last="Thapar">Anita Thapar</name><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><name sortKey="Williams, Nigel" sort="Williams, Nigel" uniqKey="Williams N" first="Nigel" last="Williams">Nigel Williams</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></region></country><country name="Italie"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></country><country name="États-Unis"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></country><country name="Australie"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></country><country name="Danemark"><noRegion><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></noRegion></country><country name="Belgique"><region name="Région flamande"><name sortKey="Hamshere, Marian L" sort="Hamshere, Marian L" uniqKey="Hamshere M" first="Marian L." last="Hamshere">Marian L. Hamshere</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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